Pyrrolizidine plant extracts as diagnostic biochemical markers on therapeutic consequences
1 State Aided College Teacher category, Department of Zoology, Sarojini Naidu College for Women, West Bengal, India.
2 Associate Professor, Department of ENT, Purulia Deven Mahato Medical College and Hospital, Purulia, West Bengal, India.
Review
International Journal of Scholarly Research in Biology and Pharmacy, 2023, 03(01), 001–009.
Article DOI: 10.56781/ijsrbp.2023.3.1.0028
Publication history:
Received on 09 May 2023; revised on 29 June 2023; accepted on 01 July 2023
Abstract:
The consumption of cereals and bakery products contaminated with seeds of species containing Pyrrolizidine alkaloids (PAs) has been involved in mass poisonings in rural areas of Afghanistan, India, South Africa and the former USSR. Poisoning can manifest as acute or subacute veno-occlusive disease with specific symptoms such as persistent hepatomegaly, leading to cirrhosis or shown to have genotoxic, mutagenic, teratogenic and carcinogenic effects.
Several such toxicity testing of PAs have been done in cultured animal cells with reference to mice model, to better understand the pathway of metabolic impairement. Also the pluripotent proprty of mice bone marrow cells show better analyzing capacity of differentiated cell lineages. Therefore this pre-analytic review aims to focus the risk evaluation methods of PA exposure on current knowledge and recent advances of metabolic pathways of different PAs. In addition, this review provides perspectives of precision toxicity assessment strategies and biomarker development for the risk control of human intoxication by PAs with eventual categorization of pyrrole-protein adducts like serum Alanine Transferase (ALT), Glutathione transferase (GSH-T), Alkaline Phosphatase (ALP) in different cell lineages grown by lab-based cell culture techniques.
Keywords:
Cell lineages; Pyrrolizidine alkaloids; Plant extracts; Genotoxicity; Protein Adducts
Full text article in PDF:
Copyright information:
Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0