On the interaction of glucose with ammonium molybdate (Hager-Gawalowsky test)
Organic Chemistry Department, Faculty of Chemistry, National Autonomous University of Mexico, Mexico City (CDMX), Mexico.
Research Article
International Journal of Scholarly Research in Chemistry and Pharmacy, 2024, 04(02), 001–003.
Article DOI: 10.56781/ijsrcp.2024.4.2.0034
Publication history:
Received on 05 September 2024; revised on 15 October 2024; accepted on 17 October 2024
Abstract:
Glucose is an Analyte. Thus, several tests for its detection in urine have been developed. In the present communication the reaction route of the Hager-Gawalowsky test for glucose is provided. Each step is fully commented and the electron flow is also given. The test is based on the interaction of glucose with ammonium molybdate in neutral medium, a blue colour is produced on heating. The active hydrogen in glucose is removed by the inorganic anion, and the resulting enolate from an enediol reacts with the mono-anion just formed. A hydroxylate is eliminated via open-close of a Mo-O double bond. Hydrion switch forms a second enolate that produces a concerted mechanism affording 2-ketoglucose and molybdenum dioxide by a redox reaction.
Keywords:
Ammonium molybdate; Hager-Gawalowsky test; 2-Ketoglucose; Molybdenum blue; Molybdenum dioxide; Reactive intermediates; Redox reaction
Full text article in PDF:
Copyright information:
Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0