A Longitudinal study on the Kinetic of T-cells and certain hematological parameters during the Initiation of antiretroviral therapy and after two years on treatment
1 Center for the Study and Control of Communicable Diseases (CSCCD), Yaoundé, Cameroon.
2 Chantal BIYA International Reference Centre for research on HIV/AIDS Prevention and Management (CBIRC), Cameroon
3 University of Yaounde 1, Cameroon.
4 African University for Peace Ethiopia.
Research Article
International Journal of Scholarly Research and Reviews, 2024, 04(02), 041–048.
Article DOI: 10.56781/ijsrr.2024.4.2.0024
Publication history:
Received on 19 February 2024; revised on 01 May 2024; accepted on 04 May 2024
Abstract:
Background: T- cell are key regulators of the immune system and their role in the initiating and follow –up of patients on antiretroviral therapy (ART) is primordial. In the present work, we compared T-cells and certain biological parameters after 2 months of ART with those obtained after one year and 2 years of ART.
Method: In this prospective cohort study, 150 HIV patients on primo ART treatment and consenting were recruited. Five ml of blood were collected at initiation (M0), after 2 months (M2), after 1 year (M12), and after 2 years (M24) of ART. CD4 cells, CD8 cells, and other hematological parameters were measured according to standard operating procedures.
Results: The 88 retained participants included 18 (20.6%) men and 70 (79.4%) women, with a mean age of 35.5 years. After 2 months, there was a significant increase in CD4 count, monocytes, and platelets with p-values of 0.001, 0.02, and 0.04, respectively, while hemoglobin and CD8 cells did not significantly change (p-values of 0.06 and 0.82, respectively). After one year and after two years of therapy, the increases in these parameters were not statistically significant compared to the values obtained at M2.
Conclusion: CD4 lymphopenia, monopénia and thrombopenia induced by HIV infection are corrected maximally during the first months after the beginning of ART and tend to stabilize over time, while anemia can continue to persist.
Keywords:
HIV; ART; Monocytopenia; Lymphopenia; Thrombopenia
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0