A comprehensive review on 2-substituted benzimidazole derivatives and its biological importance
Department of Pharmaceutical Chemistry, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, Mandya, Karnataka, 571418, India.
Review
International Journal of Scholarly Research and Reviews, 2023, 02(02), 122–134.
Article DOI: 10.56781/ijsrr.2023.2.2.0032
Publication history:
Received on 21 March 2023; revised on 21 June 2023; accepted on 24 June 2023
Abstract:
Condensation of o-phenylene-diamine with formic acid is used in the synthesis of commercially available benzimidazole. N-ribosyldimethyl benzimidazole is the most common benzimidazole compound found in nature, and it functions as an axial ligand for cobalt in vitamin B12. The benzimidazole and its derivatives are important therapeutic agents, such as antiulcer and anthelmintic drugs. Benzimidazole compounds also possess antimicrobial, antiviral, anticancer, anti-inflammatory, analgesic, and other pharmacological properties. The chemistry and pharmacological actions of substituted benzimidazoles are summarised in this article.
Keywords:
Mechanism; Therapeutic Agents; Heterocyclic Compounds; Synthetic Products
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0