Evaluation of the acute toxicity of the total aqueous extract of the stem bark of Spondias mombin L. in Wister strain rats
1 Department of Agroforestory, Jean Lorougnon Guede University, Dalao, Côte d’Ivoire.
2 Department of Science and Nature, Nangui Abrogoua University, Abidjan, Côte d’Ivoire.
Research Article
International Journal of Scholarly Research in Biology and Pharmacy, 2022, 01(02), 001–006.
Article DOI: 10.56781/ijsrbp.2022.1.2.0027
Publication history:
Received on 04 October 2022; revised on 17 November 2022; accepted on 19 November 2022
Abstract:
Background: Many medicinal plants including Spondias mombin L are used in traditional medicine for treatment of many pathology. It is therefore used for rational for remedies derived from medicinal plants.
Aim: As part of concerning traditional medecine drugs, a toxicology study was conducted on the stem bark of Spondias mombin L., remedy used to treating of diarrhea.
Materials and method: Total aqueous extract of the stem bark of this plant was orally administered at one dose of 2000 and 5000 mg/kg body weight to two (2) batches of five (5) female rats during fourteen (14) days. Five (5) female rats control group consisting received distilled water. All the animals were sacrificed after treatment, their blood and nutritional organs such as (liver and kidneys) were removed.
Results: This study showed no death was observed between the animals, however clinical signs were notified through the observation time. Indeed, the LD50 is therefore greater than 5000 mg/kg of body weight. In addition, hematological parameters analysis shows a significant increase of erythrocyte and leucocyte cells but not significant for thrombocyte cells. Therefore, it was observed, the weight of liver and kidneys significant increase.
Conclusion: Stem bark of Spondias mombin L is a power immunostimulator which could justify is using of traditional medicine traitment for pathology.
Keywords:
Spondias mombin L.; Toxicity; Hemetological parameters; Wistar strain rat
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